Attached to every clinical trial is a line of hope for a patient seeking a cure or better way to live with a rare, chronic, or limiting condition. Unfortunately, global events have disrupted the clinical trial landscape significantly in the past 2 years impacting the hope and lives of millions of people. Although rescue sites are most commonly thought of as an alternative to trials failing for more common reasons like lack of enrollment, Medical Affairs teams should be re-evaluating their overall strategy to make sure that even in the face of uncertainty, there is a path forward for clinical design. Rescue sites can provide that path forward.